Research Field

A. TRP channel laboratory
TRP ion channel research, protein-protein interaction, smooth muscle, calcium homeostasis, gastrointestinal tract motility physiology
B. Research in our laboratory is largely focused on Transient Receptor Potential (TRP) channels. TRP channels are known to mediate critical roles in maintaining calcium homeostasis in both excitable and non-excitable cells.
Since their first discovery in Drosophila Melanogaster where dtrp channels were regarded as a key component for light-induced hyperpolarization in retina to be sustained, the diverse physiological roles of TRP channels in mammalian cells have been continuously and increasingly reported in not only excitable cells such as muscles and neurons but even in non-excitable cells like immune cells, epithelial cells, hepatocytes and endothelial cells. Our research team is now focused on 1) discovering new protein candidates that may have protein-protein interaction with TRP channels, 2) how PIP2 molecules regulate open probability of TRPC channels, and 3) how TRP channels are functionally related in autosomal dominant polycystic kidney disease (ADPKD).

Pure Link

Keyword

transient receptor potential channels, protein-protein interaction, smooth muscle research, calcium homeostasis, GI motility