Research Field

Bacteria can adapt to environments that promotes its long-term survival. Pathogenic bacteria cause chronic infectious diseases in the host by evading host immune systems and antibiotics. Big question of our research team is how pathogenic bacteria respond to a variety of stresses for long-term survival. First, we will determine how pathogenic bacteria communicate with host cells to cause the chronic infections. Second, our team will establish the mechanisms of bacterial antibiotic persistence. Third, we will investigate how the mechanisms of protein homeostasis such as translation, folding, degradation regulate survival and pathogenesis in bacteria. Outcomes from these studies will potentially uncover novel strategy to control chronic infectious diseases by pathogenic bacteria.

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Keyword

Pathogenic bacteria, Host-pathogen interaction, Bacteria stress response, Antibiotic persistance, Protein homeostasis