The major interests of LND include:
- Mechanism of disease progression
- Determinants for disease specificity (eg, Alzheimer vs. Parkinson)
- Mechanism-based development of pre-symptomatic diagnosis and therapy
Specific questions to address
- What is the underlying mechanism for the ‘progression’ of neurodegenerative diseases?
- Which aggregate species are pathogenic culprit?
- What is the relationship between lysosomal storage diseases and neurodegenerative diseases?
- Why does some people get tauopathies, while others get synucleinopathies or TDP43pathies?
- Can we stop the progression of neurodegenerative diseases by interfering with protein aggregate spreading?