2022
2. Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
Joo‑Ok Min, Timo Strohäker, Byung‑Chul Jeong, Markus Zweckstetter and Seung‑Jae Lee*
1. Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy
Minsun Choi, Tae-Kyung Kim, Jinhyung Ahn, Jun Sung Lee, Byung Chul Jung, Sungwon An, Dongin Kim, Min Jae Lee, Inhee Mook-Jung, Sang Hoon Lee, Seung-Jae Lee*
2021
2. Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked DNAJC6 mutations
Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Hye-Ji Woo, Mi-Yoon Chang, Jinil Kim, Eun-Jin Bae`, Woong Sun, Ju-Hyun Lee, Il-Joo Cho, Hyogeun Shin, Seung-Jae Lee*, and Sang-Hun Lee
1. Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells
Changyoun Kim, Somin Kwon, Michiyo Iba, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Soo Jean Shin`, Jerel A. Fields, Robert A. Rissman, Seung-Jae Lee* & Eliezer Masliah
Experimental and Molecular Medicine,
2021,
Link
2020
3. LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies
Changyoun Kim, Alexandria Beilina, Nathan Smith, Yan Li, Minhyung Kim, Ravindran Kumaran, Alice Kaganovich, Adamantios Mamais, Anthony Adame, Michiyo Iba, Somin Kwon, Won-Jae Lee`, Soo-Jean Shin`, Robert A. Rissman, Sungyong You, Seung-Jae Lee*, Andrew B. Singleton, Mark R. Cookson and Eliezer Masli
2. Alpha-Synuclein Inclusion Formation in Human Oligodendrocytes
Ye-Seul Yoon†, Woo Jung Ahn†, Diadem Ricarte, Darlene Ortiz, Chan Young Shin, Seung-Jae Lee*, He-Jin Lee
1. Changes in plasma arylsulfatase A level as a compensatory biomarker of early Parkinson's disease.
Han Soo Yoo, Jun Sung Lee`, Seok Jong Chung, Byoung Seok Ye, Young H. Sohn, Seung-Jae Lee* & Phil Hyu Lee
2019
6. The LRRK2-RAB axis in regulation of vesicle trafficking and α-synuclein propagation.
Eun-Jin Bae`, Seung-Jae Lee*
5. Models of multiple system atrophy.
He-Jin Lee, Diadem Ricarte, Darlene Ortiz & Seung-Jae Lee*
4. Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
Timo Strohäker, Byung Chul Jung`, Shu-Hao Liou, Claudio O. Fernandez, Dietmar Riedel, Stefan Becker, Glenda M. Halliday, Marina Bennati, Woojin S. Kim, Seung-Jae Lee* & Markus Zweckstetter
3. Modeling α-Synuclein Propagation with Preformed Fibril Injections.
Hyun Kyung Chung`, Hoang-Anh Ho`, Dayana Pérez-Acuña`, Seung-Jae Lee*
2. Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone.
Jun Sung Lee`, Kazuaki Kanai, Mari Suzuki, Woojin S Kim, Han Soo Yoo, YuHong Fu, Dong-Kyu Kim, Byung Chul Jung, Minsun Choi, Kyu Won Oh, Yuanzhe Li, Mitsuyoshi Nakatani, Tomoko Nakazato, Satoko Sekimoto, Manabu Funayama, Hiroyo Yoshino, Shin-ichiro Kubo, Kenya Nishioka, Ryusuke Sakai, Morio Ueyama,
1. Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.
Ruth E. Musgrove, Michael Helwig, Eun-Jin Bae, Helia Aboutalebi, Seung-Jae Lee, Ayse Ulusoy, and Donato A. Di Monte
2018
4. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.
Changyoun Kim, Brian Spencer, Edward Rockenstein, Hodaka Yamakado, Michael Mante, Anthony Adame, Jerel Adam Fields, Deborah Masliah, Michiyo Iba, He-Jin Lee, Robert A. Rissman, Seung-Jae Lee and Eliezer Masliah
3. LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.
Eun-Jin Bae*, Dong-Kyu Kim*, Changyoun Kim, Michael Mante, Anthony Adame, Edward Rockenstein, Ayse Ulusoy, Michael Klinkenberg, Ga Ram Jeong, Jae Ryul Bae, Cheolsoon Lee, He-Jin Lee, Byung-Dae Lee, Donato A. Di Monte, Eliezer Masliah, Seung-Jae Lee
2. Non-cell-autonomous actions of α-synuclein: Implications in glial synucleinopathies
Somin Lim, Han-Joon Kim, Dong-Kyu Kim, Seung-Jae Lee
1. Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction.
He-Jin Lee, Ye-Seul Yoon, Seung-Jae Lee
2017
5. Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans
Dong-Kyu Kim, Kyu-Won Cho, Woo Jung Ahn, Dayana Perez-Acuña, Hyunsu Jeong, He-Jin Lee, and Seung-Jae Lee
4. Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.
Ye-Seul Yoon, Eun-Duk Cho, Woo Jung Ahn, Kyung Won Lee, Seung-Jae Lee and He-Jin Lee
3. Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?
Yoon-Ju Lim and Seung-Jae Lee
2. Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy.
Omar El-Agnaf, Cassia Overk, Edward Rockenstein, Michael Mante, Jazmin Florio, Anthony Adame, Nishant Vaikath, Nour Majbour, Seung-Jae Lee, Changyoun Kim, Eliezer Masliah, Robert A. Rissman
1. Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification.
Byung Chul Jung, Yoon-Ju Lim, Eun-Jin Bae, Jun Sung Lee, Min Sun Choi, Michael K. Lee, He-Jin Lee, Yoon Suk Kim, Seung-Jae Lee
2016
9. Mechanisms of Aging-related proteinopathies in Caenorhabditis elegans
Dong-Kyu Kim, Tae Ho Kim, Seung-Jae Lee
8. Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2.
Changyoun Kim, He-Jin Lee, Eliezer Masliah, Seung-Jae Lee
7. Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.
Changyoun Kim, Guohua Lv, Jun Sung Lee, Byung Chul Jung, Masami Masuda-Suzukake, Chul-Suk Hong, Elvira Valera, He-Jin Lee, Seung R. Paik, Masato Hasegawa, Eliezer Masliah, David Eliezer & Seung-Jae Lee
6. Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.
Dong-Kyu Kim, Hee-Sun Lim, Ichiro Kawasaki, Yhong-Hee Shim, Nishant N. Vaikath, Omar M. A. El-Agnaf, He-Jin Lee, Seung-Jae Lee
5. Neuroinflammation in Synucleinopathies
Somin Lim, Yewon Chun, Jun Sung Lee, Seung-Jae Lee
4. α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.
Brian Spencer, Changyoun Kim, Tania Gonzalez, Alejandro Bisquertt, Christina Patrick, Edward Rockenstein, Anthony Adame, Seung-Jae Lee, Paula Desplats, Eliezer Masliah
3. Mechanism of Anti-α-Synuclein Immunotherapy
Jun Sung Lee, Seung-Jae Lee
2. Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model.
Se Hee Oh, Ha Na Kim, Hyun Jung Park, Jin Young Shin, Eun-Jin Bae, Mun Kyung Sunwoo, Seung-Jae Lee, Phil Hyu Lee
1. Cell Models to Study Cell-to-Cell Transmission of α-Synuclein
Eun-Jin Bae, He-Jin Lee, Seung-Jae Lee
2015
6. FcγRIIB mediates the inhibitory effect of aggregated α-synuclein on microglial phagocytosis.
Yu Ree Choi, Seo-Jun Kang, Jin-Mo Kim, Seung-Jae Lee, Ilo Jou, Eun-Hye Joe, Sang Myun Park
5. Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
Nishant N. Vaikath, Nour K. Majbour, Katerina E. Paleologou, Mustafa T. Ardah, Esther van Dam, Wilma D.J. van de Berg, Shelley L. Forrest, Laura Parkkinen, Wei-Ping Gai, Nobutaka Hattori, Masashi Takanashi, Seung-Jae Lee, David M.A. Mann, Yuzuru Imai, Glenda M. Halliday, Jia-Yi. Li, Omar M.A. El-Agn
4. Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.
Changyoun Kim, Edward Rockenstein, Brian Spencer, Hyung-Koo Kim, Anthony Adame, Margarita Trejo, Klodjan Stafa, He-Jin Lee, Eliezer Masliah, Seung-Jae Lee
3. Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates.
Eun-Jin Bae, Na Young Yang, Cheolsoon Lee, Seokjoong Kim, He-Jin Lee, Seung-Jae Lee
1. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation.
Eun-Jin Bae, Na-Young Yang, Cheolsoon Lee, He-Jin Lee, Seokjoong Kim, Sergio Pablo Sardi, Seung-Jae Lee
2014
7. ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells.
Eun-Jin Bae, Cheolsoon Lee, He-Jin Lee, Seokjoong Kim, Seung-Jae Lee
6. Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.
Eun-Jin Bae, Na-Young Yang, Miyoung Song, Cheol Soon Lee, Jun Sung Lee, Byung Chul Jung, He-Jin Lee, Seokjoong Kim, Eliezer Masliah, Sergio Pablo Sardi, Seung-Jae Lee
5. The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
Ossama Khalaf, Bruno Fauvet, Abid Oueslati, Igor Dikiy, Anne-Laure Mahul-Mellier, Francesco Simone Ruggeri, Martial K. Mbefo, Filip Vercruysse, Giovanni Dietler, Seung-Jae Lee, David Eliezer, Hilal A. Lashuel
4. The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
Mohamed-Bilal Fares, Nadine Ait-Bouziad, Igor Dikiy, Martial K. Mbefo, Ana Jovičić, Aoife Kiely, Janice L. Holton, Seung-Jae Lee, Aaron D. Gitler, David Eliezer, Hilal A. Lashuel
3. Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates
Eun-Jin Bae, He-Jin Lee, Y-H Jang, S Michael, Eliezer Masliah, D S Min, Seung-Jae Lee
2. β1-integrin-dependent migration of microglia in response to neuron-released α-synuclein.
Changyoun Kim, Eun-Deok Cho, Hyung-Koo Kim, Sungyong You, He-Jin Lee, Daehee Hwang, Seung-Jae Lee
1. Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.
He-Jin Lee, Eun-Jin Bae, Seung-Jae Lee
2013
6. LRRK2 as a potential genetic modifier of synucleinopathies: Interlacing the two major genetic factors of Parkinson’s disease
Cheol Hwan Hyun*, Chae Young Yoon*, He-Jin Lee, Seung-Jae Lee
5. Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein.
He-Jin Lee, Eun-Duk Cho, Kyung Won Lee, Jung-Hyun Kim, Ssang-Goo Cho, Seung-Jae Lee
4. Glucocerebrosidase, a new player changing the old rules in Lewy body diseases.
Na-Young Yang, Yu-Na Lee, He-Jin Lee, Yoon Suk Kim, Seung-Jae Lee
3. Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.
Changyoun Kim, Dong-Hwan Ho, Ji-Eun Suk, Sungyong You, Sarah Michael, Junghee Kang, Sung Joong Lee, Eliezer Masliah, Daehee Hwang, He-Jin Lee, Seung-Jae Lee
2. Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein.
Eun-Jin Bae*, Dong-Hwan Ho*, Eun-Bi Park, Jin Woo Jung, Kyungcho Cho, Ji Hye Hong, He-Jin Lee, Kwang Pyo Kim, Seung-Jae Lee
1. The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking
Ye-Jin Chai, Dong-Kyu Kim, Joohyun Park, Haiyan Zhao, Seung-Jae Lee, Sunghoe Chang
2012
4. Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.
Eun-Jin Bae, He-Jin Lee, Edward Rockenstein, Dong-Hwan Ho, Eun-Bi Park, Na-Young Yang, Paula Desplats, Eliezer Masliah, Seung-Jae Lee
3. Proteolytic cleavage of extracellular α-synuclein by plasmin: implications for Parkinson disease.
Kwang Soo Kim, Yu Ree Choi, Ji-Young Park, Jung-Ho Lee, Dong Kyu Kim, Seung-Jae Lee, Seung R. Paik, Ilo Jou, Sang Myun Park
2. A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV
Young Han Lee, Seung-Hyun Jeon, Se Hyun Kim, Changyoun Kim, Seung-Jae Lee, Dongsoo Koh, Yoongho Lim, Kyooseob Ha,corresponding author, Soon Young Shin
1. Cell-to-cell transmission of α-synuclein aggregates.
Seung-Jae Lee, Paula Desplats, He-Jin Lee, Brian Spencer, Eliezer Masliah
2011
4. Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice.
He-Jin Lee, Ji-Eun Suk, Kyung-Won Lee, Seung-Hwa Park, Peter C. Blumbergs, Wei-Ping Gai, Seung-Jae Lee
3. Enzyme-linked immunosorbent assays for α-synuclein with species and multimeric state specificities.
He-Jin Lee*, Eun-Jin Bae*, Ara Janga, Dong-Hwan Ho, Eun-Duk Cho, Ji-Eun Suk, Yeo-Min Yun, Seung-Jae Lee
2. Protein aggregate spreading in neurodegenerative diseases: problems and perspectives
Seung-Jae Lee, Hee-Sun Lim, Eliezer Masliah, He-Jin Lee
1. Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
He-Jin Lee, Sung Min Baek, Dong-Hwan Ho, Ji-Eun Suk, Eun-Duk Cho, Seung-Jae Lee
2010
5. Cell-to-cell transmission of non-prion protein aggregates.
Seung-Jae Lee, Paula Desplats, Christina Sigurdson, Igor Tsigelny & Eliezer Masliah
4. Alpha-synuclein stimulation of astrocytes: Potential role for neuroinflammation and neuroprotection.
He-Jin Lee, Changyoun Kim, Seung-Jae Lee
3. Multiple non-cell autonomous actions of alpha-synuclein in neurodegenerative diseases: Is there a direct link?
Seung-Jae Lee, He-Jin Lee, Eliezer Masliah
2. Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions
Ara Jang, He-Jin Lee, Ji-Eun Suk, Jin-Woo Jung, Kwang-Pyo Kim, Seung-Jae Lee
1. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.
He-Jin Lee, Ji-Eun Suk, Christina Patrick, Eun-Jin Bae, Ji-Hoon Cho, Sangchul Rho, Daehee Hwang, Eliezer Masliah, Seung-Jae Lee
2009
3. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.
Paula Desplats, He-Jin Lee, Eun-Jin Bae, Christina Patrick, Edward Rockenstein, Leslie Crews, Brian Spencer, Eliezer Masliah, Seung-Jae Lee
2. Topographical Propagation of α-synuclein Pathology in Parkinson's Disease: Phenomenology and Hypothetical Mechanism
Minsuk Hyun, Seung-Jae Lee
1. Egr-1 is necessary for fibroblast growth factor-2-induced transcriptional activation of the glial cell line-derived neurotrophic factor in murine astrocytes.
Soon Young Shin, Haengseok Song, Chang Gun Kim, Yang-Kyu Choi, Kyoung Sun Lee, Seung-Jae Lee, He-Jin Lee, Yoongho Lim, Young Han Lee
2008
5. Alpha-synuclein is localized in a subpopulation of rat brain synaptic vesicles.
Seung-Jae Lee, Hyesung Jeon, Konstantin V. Kandror
4. Controlling the mass action of alpha-synuclein in Parkinson's disease.
Changyoun Kim, Seung-Jae Lee
3. Clearance and deposition of extracellular alpha-synuclein aggregates in microglia
He-Jin Lee, Ji-Eun Suk, Eun-Jin Bae, Seung-Jae Lee
2. Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein
He-Jin Lee, Ji-Eun Suk, Eun-Jin Bae, Jung-Ho Lee, Seung R. Paik, Seung-Jae Lee
1. Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease.
Seung-Jae Lee