2014년 7월 한국을 빛낸사람들- 김효수교수

2015-02-04l 조회수 4920

Journal of the American College of CardiologyVolume 63, Issue 25, Part A, 1 July 2014, Pages 2805–2816 A Randomized Comparison of Platinum Chromium-Based Everolimus-Eluting Stents Versus Cobalt Chromium-Based Zotarolimus-Eluting Stents in All-Comers Receiving Percutaneous Coronary Intervention : HOST–ASSURE (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis–Safety & Effectiveness of Drug-Eluting Stents & Anti-platelet Regimen), a Randomized, Controlled, Noninferiority Trial Kyung Woo Park, MD, PhD1; Si-Hyuck Kang, MD, MSc1; Hyun-Jae Kang, MD, PhD1; Bon-Kwon Koo, MD, PhD1; Byoung-Eun Park, MD, PhD2; Kwang Soo Cha, MD, PhD3; Jay Young Rhew, MD, PhD4; Hui-Kyoung Jeon, MD, PhD5; Eun-Seok Shin, MD, PhD6; Ju Hyeon Oh, MD, PhD7; Myung-Ho Jeong, MD, PhD8; Sanghyun Kim, MD, PhD9; Kyung-Kuk Hwang, MD, PhD10; Jung-Han Yoon, MD, PhD11; Sung Yun Lee, MD, PhD12; Tae-Ho Park, MD, PhD13; Keon Woong Moon, MD, PhD14; Hyuck-Moon Kwon, MD, PhD1; Seung-Ho Hur, MD, PhD16; Jae-Kean Ryu, MD, PhD17; Bong-Ryul Lee, MD, PhD18; Yong Whi Park, MD, PhD19; In-Ho Chae, MD, PhD20; Hyo-Soo Kim, MD, PhD15 1 Seoul National University Hospital, Seoul, Korea 2 Dankook University Hospital, Cheonan, Korea 3 Busan National University Hospital, Busan, Korea 4 Presbyterian Medical Center, Jeonju, Korea 5 Uijeongbu St. Mary’s Hospital, Uijeongbu, Korea 6 Ulsan University Hospital, Ulsan, Korea 7 Samsung Changwon Hospital, Changwon, Korea 8 Chonnam National University Hospital, Gwangju, Korea 9 Boramae Medical Center, Seoul, Korea 10 Chungbuk National University Hospital, Cheongju, Korea 11 Wonju Christian Hospital, Wonju, Korea 12 Inje University Ilsan Paik Hospital, Goyang, Korea 13 Dong-A Medical Center, Busan, Korea 14 St. Vincent’s Hospital, Suwon, Korea 16 Keimyung University Dongsan Medical Center, Daegu, Korea 17 Daegu Catholic University Medical Center, Daegu, Korea 18 Daegu Fatima Hospital, Daegu, Korea 19 Gyeongsang National University Hospital, Jinju, Korea 20 Seoul National University Bundang Hospital, Seongnam, Korea 15 Gangnam Severance Hospital, Seoul, Korea Dr. K. W. Park and Dr. S.-H. Kang contributed equally to this work.
Abstract OBJECTIVES: This study sought to test whether the newly developed platinum chromium (PtCr)-based everolimus-eluting stent (EES) is noninferior to the cobalt chromium (CoCr)-based zotarolimus-eluting stent (ZES) in all-comers receiving percutaneous coronary intervention (PCI). BACKGROUND: PtCr provides improved radial strength, conformability, and visibility compared with the CoCr alloy, but PtCr-based stents have not been tested in a wide range of patients receiving PCI. Also, recent case series have raised the issue of longitudinal stent deformation (LSD) with newer drug-eluting stents. METHODS: We randomly assigned 3,755 all-comers receiving PCI to PtCr-EES or CoCr-ZES. The primary outcome was target lesion failure (TLF) at 1-year post-PCI, defined as the composite of cardiac death, nonfatal target vessel-related myocardial infarction, and ischemia-driven target lesion revascularization. Post-hoc angiographic analysis was performed to qualitatively and quantitatively analyze LSD. RESULTS: At 1 year, TLF occurred in 2.9% and 2.9% of the population in the PtCr-EES and CoCr-ZES groups, respectively (superiority p = 0.98, noninferiority p = 0.0247). There were no significant differences in the individual components of TLF as well as the patient-oriented clinical outcome. Of 5,010 stents analyzed, LSD occurred in 0.2% and 0% in the PtCr-EES and CoCr-ZES groups, respectively (p = 0.104). There was no significant difference in post-deployment stent length ratio between the 2 stents (p = 0.352). CONCLUSIONS: Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. KEYWORDS: all-comers trial; clinical outcome; drug-eluting stent(s); percutaneous coronary intervention Category: Medicine ▷ BRIC > 한빛사 > 한빛사논문 > 2014년 7월

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2014년 7월 한국을 빛낸사람들- 김효수교수