2013년 1학기 우수의과학자 초청 세미나 13주차
- 연사 : 김현석 교수(이화여대)
- 연제 : The significance of protein lysine acetylation in aging and aging-related diseases: In aspects of Sirtuins KO mice model (Sirt2, Sirt3, and Sirt6)
- 일시 : 2013년 6월 4일(화) PM 2:00
- 장소 : 함춘강의실
- 문의 : 02-740-8095
대표발표논문:
1. SIRT2 Maintains Genomic Instability and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell, 20(4):487-499, 2011 Oct.
2. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 285:36776-84, 2010 Nov.
3. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metabolism. 12:224-36, 2010 Sep.
4. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 17:41-52, 2010 Jan.
5. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci. 105:14447-52, 2008 Sep.
