Department of Biomedical Sciences, SNU

2013년 2학기 우수의과학자 초청 세미나 8주차

  • 연사 : 2시임지홍 박사(건국대학교)
    3시Gabriel Nunez(Univ. Michigan Medical School)
  • 연제 : 2시 : PGC1a (PPARGC1A) Defines the Metabolic State of Melanoma Cells
    3시 : Linking Pathogen Virulence, the Microbiota and Disease
  • 일시 : 2013년 11월 6일(수) PM 2:00
  • 장소 : 함춘강의실
  • 문의 : 02-740-8095
대표발표논문 임지홍 박사 (2013) PGC1alpha Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress. Cancer Cell 23(3):287-301 (2012) The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+. Molecular Cell 44(6):851-63 (2011) Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1 alpha pre-mRNA in mice and in vitro. Hepatology 53(1):171-80. (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1 alpha.Molecular Cell 38(6):864-78. (2008) Hypoxia-inducible factor 1 alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin. Cancer Research 68(13):5177-84. Prof. Gabriel Nunez (2013) K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 27;38(6):1142-53. (2013) Induction of bone loss by pathobiont-mediated nod1 signaling in the oral cavity. Cell Host Microbe 13:595-601. (2013) NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 123:700-711 (2012) Critical Role for Mast Cells in IL-1β-Driven Skin Inflammation Induced by an Activating Nlrp3 mutation. Immunity 1:85-95 (2012) DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 4:847-859