주요발표논문 UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc. Natl. Acd. Sci. USA. 2010 Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. Proc. Natl. Acad. Sci. USA. 2008 Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proc. Natl. Acad. Sci. USA. 2006 Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat. Genet. 2005 RECQ4, mutated in the Rothmund-Thomson and Rapadilino syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Hum. Mol. Genet. 2004 An essential role of N-terminal arginylation in cardiovascular development. Science . 2002