2008년도 1학기 우수의과학자 특강 9주차
- Speaker : 박정현 박사 (NIH/NCI)
- Topic : Coreceptor Tuning: A new IL-7 driven homeostatic model for promoting naïve CD8 T cell survival
- Date : 2008년 5월 8일(목) 오후 1시30분
- Location : 함춘강의실
- Inquiry : 의과학과 사무실 02-740-8095
주요 발표 논문:
Deletion of CD4/CD8 coreceptors permits generation of αβT cells that recognize
Antigens independently of MHC. Immunity. 2007
'Coreceptor Tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat. Immunol. 2007
Cytokine signal transduction is suppressed in preselection double positive thymocytes and restored by positive selection. J. Exp Med. 2006
IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgt: impact on thymocyte development. J. Exp Med. 2004
Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a
novel mechanism for maximizing IL-7-dependent T cell survival. Immunity. 2004