2010년1학기 우수의과학자 초청 세미나 13주차
- Speaker : 권 용 태 박사(U.Pittsburgh/서울대)
- Topic : Regulated Proteolysis by Protein N-terminus: Its Role in Cardiovascular Homeostasis and Chromatin Dynamics
- Date : 2010년 6월 17(목) 오전 10:00
- Location : 의생명과학관 115호
- Inquiry : 02-740-8095
주요발표논문
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc. Natl. Acd. Sci. USA. 2010
Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. Proc. Natl. Acad. Sci. USA. 2008
Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proc. Natl. Acad. Sci. USA. 2006
Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat. Genet. 2005
RECQ4, mutated in the Rothmund-Thomson and Rapadilino syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Hum. Mol. Genet. 2004
An essential role of N-terminal arginylation in cardiovascular development. Science . 2002
