Department of Biomedical Sciences, SNU
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Shin, hyun-woo

M.D., Ph.D. / Professor
Obstructive Upper airway Research (OUaR) Laboratory
TEL +82-2-740-8285
FAX 02-745-7996
E-MAIL charlie@snu.ac.kr
WEBSITE http://sites.google.com/view/ouarlab

Research

Research Field
We are conducting research to identify the etiology of upper airway obstructive disease and to devise new diagnosis and treatment methods.
In particular, we are interested in Chronic Rhinosinusitis with Nasal Polyps and Obstructive Sleep Apnea (OSA), which are typical upper airway obstruction diseases.

-Endotype analysis to understand chronic sinusitis, a disease with very high heterogeneity
-Exploring new treatments by identifying the remodeling mechanism of nasal mucosa in nasal polyps, which is often accompanied by chronic sinusitis patients
-Discovering biomarkers for early diagnosis and effective follow-up of sleep apnea
-A study on the mechanism of cancer metastasis and progression due to intermittent hypoxia occurring in patients with sleep apnea
Pure Link
https://snucm.elsevierpure.com/en/persons/hyun-woo-shin
Keyword
Airway Epithelial Remodeling, Intermittent Hypoxia, Obstructive Sleep Apnea, Nasal polyp, Upper Airway Obstruction, Biomarker and Metabolomics
Intensive Major
# Molecular cell
# Omics Medicine

Education

  • Ph.D., Seoul National University Graduate School, Biomedical sciences (2012)
  • M.S., Seoul National University College of medicine, Otorhinolaryngology (2009)
  • M.D., Seoul National University College of medicine (2004)

Career

  • Associate Professor, Seoul National University College of Medicine/Seoul National University Hospital (2018.3-current)
  • Visiting Faculty, Stanford University School of Medicine (2017.9-2019.8)
  • Assistant Professor, Seoul National University College of Medicine/Seoul National University Hospital (2014-2018)
  • Research Professor, Seoul National University Medical Research Center (2013-2014)
  • Biomedical Research Fellow, Seoul National University Graduate School (2012-2013)
  • Research and Teaching Assistant, Seoul National University College of Medicine (2009-2012)
  • Resident, Seoul National University Hospital, Department of Otorhinolaryngology-Head and Neck Surgery (2005-2009)
  • Intern, Seoul National University Hospital (2004)

Publication

  1. DEP-induced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition. Journal of Allergy and Clinical Immunology 2021 (corresponding, IF=10.793)
  2. Bone morphogenetic protein-2 as a novel biomarker for refractory chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology 2021 (co-corresponding, IF=10.793)
  3. Antibiotic-dependent relationships between the nasal microbiome and secreted proteome in nasal polyps. Allergy Asthma Immunol Research 2021 (corresponding, IF=5.764)
  4. Effects of Wnt signaling on epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyp. Thorax. 2020;75:982-993. (co-corresponding, IF=10.844)
  5. α-Helical cell-penetrating peptide-mediated nasal delivery of resveratrol for inhibition of epithelial-to-mesenchymal transition. J Control Release. 2020 Jan 10;317:181-194. (co-corresponding, IF=9.776)
List
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