Lee, dong-sup
M.D., Ph.D. / Professor
Laboratory of Immune Systemic Interactome in Cancer & Kidney (ISICK)
TEL +82-2-740-8202
FAX 02-3673-2167
E-MAIL dlee5522@snu.ac.kr
Research
Research Field
Our research primarily focuses on the mutual interactions between innate/adaptive immune cells and the cancer cells, especially the cancer stem cells. We have discovered key mediators of cancer metastasis which also affect cancer stemness, therapy resistance, and immune evasion through patient-derived xenograft (PDX) technology and thus derived PDX metastasis models. We are intensively studying the immune regulation mechanisms underlying major immune/inflammatory diseases and cancer metastasis. As comprehensive cross-talks have been suggested among various systems in our body, i.e. immune system, endocrine system, nervous system, and tissue repair system in both normal and malignant conditions, we are evaluating the pathophysiological mechanisms of cancer metastasis and therapy resistance by accessing the cross-talks among different systems centering on body/tissue homeostasis system. Based on these studies, we are also focusing on the development of activatable, in situ, and neo-epitope targeting therapeutic cancer vaccines using state of art technologies, i.e. oncolytic virotherapy, exosome-mimetic nanovesicle therapy, and photodynamic immunotherapy to overcome therapy resistant cancer stem cells.Keyword
Cancer metastasis, Cancer stem cells, Immune-Cancer cross-talk, Immune regulation, Tissue-resident immune cells, Tissue-Immune cross-talk, Kidney inflammation & homeostasisEducation
- 1982-1988 BS, Seoul National University College of Medicine (Medicine)
- 1988-1990 MS, Seoul National University College of Medicine (Neuroscience)
- 1990-1996 Ph.D., Seoul National University College of Medicine (Neuroscience)
Career
- 1991-1993 Full-time instructor, Dankook University College of Medicine
- 1993-1996 Researcher(alternative military service), Food and Drug Safety, Korea
- 1996-2000 PostDoc, The Scripps Research Institute, Department of Immunology
- 2000-Present Professor, Seoul National University College of Medicine
Publication
- “A nanostructured phthalocyanine/albumin supramolecular assembly for fluorescence turn-on imaging and photodynamic immunotherapy.” ACS Nano. 2021. Accepted
- “Kidney VISTA prevents IFNγ-IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury.” J Clin Invest. 2021. Accepted
- “Cancer Stem Cells in the Immune Microenvironment.” Adv Exp Med Biol. 1187: 245-266, 2021. doi: 10.1007/978-981-32-9620-6_12.
- “In Vivo-assembled phthalocyanine/albumin supramolecular complexes combined with a hypoxia-activated prodrug for enhanced photodynamic immunotherapy of cancer.” Biomaterials. 266: 120430, 2021. doi: 10.1016/j.biomaterials.2020.120430.
- “Kidney residency of VISTA-positive macrophages accelerates repair from ischemic injury.” Kidney Int. 97(5): 980-994, 2020. doi: 10.1016/j.kint.2019.11.025.
- “Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d.” ACS Med Chem Lett. 10(5): 773-779, 2019. doi: 10.1021/acsmedchemlett.9b00026.
