Lee, min-jae
Ph.D. / Associate professor
Research
Research Field
Dr. Min Jae Lee is Associate Professor at the Department of Biochemistry & Molecular Biology, Seoul National University College of Medicine in Korea. His research interests are intracellular protein degradation through the ubiquitin-proteasome system and autophagy, its pathophysiological implications, and development of pharmacological methods. Based on our understanding through various experimental methods in biochemistry, molecular biology, cell biology, and chemical biology, he is exploring a possibility of modulating the system. This will be applied to develop novel therapeutic, mechanism-modifying drugs of various human diseases such as cancer, metabolic diseases, and neurodegenerative diseases. He has authored 57 research papers with > 3,000 total citations, including Nature, Nature Communications, PNAS, Cell Reports and Autophagy, and currently an Editorial Board member of Journal of Alzheimer’s Disease and BMB Reports. He was the recipient of the Research Excellent Prize of Korean Chemical Society in 2016, Young Scientist Award and Sasuk Award of Korean Society of Biochemistry and Molecular Biology in 2018 and 2019, respectively.Keyword
ubiquitin, proteasome, autophagy, tau, Alzheimer's diseaseEducation
- 2002-2007 Ph.D., University of Pittsburgh School of Pharmacy, Department of Pharmaceutical Sciences
- (Major: Pharmaceutical Science)
- 2000-2002 M.S., Seoul National University, Department of Chemistry (Major: Biochemistry)
- 1993-2000 B.S., Seoul National University, Department of Chemistry
- (1995-1997, served in the ROK Army)
Career
- 2015 - present: Assistant/Associate Professor, Seoul National University College of Medicine
- Department of Biochemistry and Molecular Biology; Department of Biomedical Sciences
- 2011 - 2015: Assistant Professor, Kyung Hee University, Department of Applied Chemistry
- 2007 - 2011: Postdoctoral Fellow, Harvard Medical School, Department of Cell Biology
Publication
- Choi, W. H., Yun, Y., Park, S., Jeon, J. H., Lee, J., Yang, S., Jung, C. H., Lee, J. H., Kim, N.-K., Kwon, Y. T., Han, D., Lim, S. M., and Lee, M. J., “Aggresomal sequestration and STUB1-mediated ubiquitination during mammalian proteaphagy of inhibited proteasomes” Proc Natl Acad Sci USA 117, 19190-19200 (2020) ------------ IF 11.205 (Top 10% in Multidisciplinary Sciences)
- Kim, E., Park, S., Lee., J. H., Choi, W. H., Lee, J., Kim, J. H., Park, D. H., Choi, E. K., Kim, H. M., Kim, Y. K., Kim, K. P., Kang, M.-J., Lee, M. J. "Dual function of USP14 deubiquitinase in cellular proteasomal activity and autophagic flux" Cell Reports 24, 732-743 (2018) ------------- IF 9.423
- Choi, T. S., Lee, J., Han, J. Y., Chung, B. C., Wonkongkathep, P., Loo, J. A., Lee., M. J.*, Kim, H. I.* "Supramolecular modulation of structural polymorphism in pathogenic a-synuclein fibrils using Cu(II) coordination " Angewandte Chemie International Edition 57, 3099-3103 (2018) (*: co-corresponding authors) ------------- IF 15.336 (Top 10% in Multidisciplinary Chemistry)
- Choi, W. H., de Poot, S., Lee, J. H., Kim, J. H., Han, D. H., Kim, Y. K., Finley, D., & Lee, M. J. "Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation" [link] Nature Communications 7, 10963, doi:10/1038/ncomms10963 (2016) -------------- IF 14.919 (Top 10% in Multidisciplinary Sciences)
- Jiang, Y., Lee, J., Lee, J. H., Lee, J. W., Kim. J. H., Choi, W. H., Yoo, Y. D., Cha-Molstad, H., Kim, B. Y., Kwon, Y. T., Noh, S. A., Kim, K. P., & Lee, M. J. "The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic protein" [link] Autophagy 12, 2197-2212 (2016) --------------- IF 16.016 (Top 10% in Cell Biology)
