Kwon, obin
M.D., Ph.D. / Associate Professor
BRAIN-MD (Biochemistry Research Applied In Neuroscience & Metabolic Disorders)
TEL +82-2-740-8240
FAX 02-3668-7897
E-MAIL obinkwon@snu.ac.kr
Research
Research Field
In modern society, the prevalence of metabolic diseases and the resulting morbidity/mortality is rapidly increasing. Complex mechanisms including central nervous system (brain) and peripheral organs regulate energy metabolism. The central nervous system also primarily controls thoughts, emotions, and behaviors, and these functions can be modulated by changes in energy metabolism.Based on endocrinology and neuroscience, we pursue to reveal the unknown mechanisms under metabolic diseases (diabetes, obesity, etc.) and brain diseases (depression, dementia, epilepsy, etc.) and their novel treatment targets. In addition, we investigate how the taste and nutrient sensing affect energy metabolism and brain function. For this purpose, basic/translational researches with animal (mouse) models and human samples through systematic and integrative analysis are ongoing.
Keyword
Energy metabolism and metabolic diseases, Neuroscience, Gut-brain axisEducation
- 2015 Ph.D. of Medical Science (Neuroscience), Graduate School, Yonsei University
- 2010 Master of Medicine, Graduate School, Yonsei University
- 2005 Bachelor of Medicine (MD), Yonsei University College of Medicine
Career
- 2005-2010 Internship & Residency (Internal Medicine) Severance Hospital, Korea
- 2010-2015 Teaching Assistant in Physician-Scientist Program, Yonsei University College of Medicine, Korea
- 2015-2017 Clinical Fellowship, Division of Endocrinology & Metabolism, Asan Medical Center, Korea
- 2017-2018 Postdoctoral Fellowship, Harvard Medical School / McLean Hospital, MA, USA
- 2018-current Assistant Professor, Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Korea
Publication
- Setoyama D*, Han D*, Tian J, Lee HY, Shin HS, Nga HT, Nguyen TL, Moon JS, Jang HJ, Kim E, Choe SK, Ju SH, Choi DE, Kwon O†, Yi HS†. Comparative Analysis of Primary Sarcopenia and End-Stage Renal Disease-Related Muscle Wasting Using Multi-Omics Approaches. J Cachexia Sarcopenia Muscle. 2025 Apr;16(2):e13749. (†Co-corresponder)
- Kim HJ*, Kim B*, Kim DK, Kim H, Choi SH, Kim DH, Choi M, Mook-Jung I, Jeong YT†, Kwon O†, Phosphorylated tau in the taste buds of Alzheimer’s disease mouse models. Exp Neurobiol. 2024 Aug 31;33(4):202-214. (†Co-corresponder) [featured on the Issue Cover in Exp Neurobiol]
- Tran LT*, Park S*, Kim SK, Lee JS, Kim KW†, Kwon O†. Hypothalamic control of energy expenditure and thermogenesis. Exp Mol Med. 2022 Apr;54(4):358-369. (†Co-corresponder)
- Shin S*, Kwon O*, …, Kim CH, Kim DG. mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress. Nat Neurosci. 2015 Jul;18(7):1017-24.
- Kwon O, Kang ES, …, Kim CH. GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus. Metabolism. 2014 Nov;63(11):1455-61.
