Research Field

In modern society, the prevalence of metabolic diseases and the resulting morbidity/mortality is rapidly increasing. Complex mechanisms including central nervous system (brain) and peripheral organs regulate energy metabolism. The central nervous system also primarily controls thoughts, emotions, and behaviors, and these functions can be modulated by changes in energy metabolism.
Based on endocrinology and neuroscience, we pursue to reveal the unknown mechanisms under metabolic diseases (diabetes, obesity, etc.) and brain diseases (depression, dementia, epilepsy, etc.) and their novel treatment targets. In addition, we investigate how the taste and nutrient sensing affect energy metabolism and brain function. For this purpose, basic/translational researches with animal (mouse) models and human samples through systematic and integrative analysis are ongoing.

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Keyword

Energy metabolism and metabolic diseases, Neuroscience, Gut-brain axis, Taste