Department of Biomedical Sciences, SNU
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Lee, Won-Woo

DVM, Ph.D. / Professor
Laboratory of Autoimmunity and Inflammation
TEL +82-2-740-8303
FAX 02-743-0881
E-MAIL wonwoolee@snu.ac.kr
WEBSITE http://lai.snu.ac.kr/

Research

Research Field
Dr. Lee has been committed to deciphering molecular and cellular mechanisms for pathogenesis of autoimmune disorders. Our understanding of autoimmunity has improved greatly during the past two decades but etiology of most human autoimmune diseases still remains obscure. His research is mainly focused on identifying novel molecular targets and pathways in autoimmune diseases by utilizing relevant and bioinformative model systems, and innovative cytomics techniques. In addition, his research efforts are concentrated on elucidating mechanisms underlying the age-related immune degeneracy (immunosenescence) with identifying selective defects the immune system, examining their functional relevance, and developing therapeutic strategies to delay aging and rejuvenate immune function.
Pure Link
https://snucm.elsevierpure.com/en/persons/won-woo-lee
Keyword
Human immunology, Immunosenescence, Th17-Treg balance, Inflammatory monocytes/macrophage, Immunometabolism, Metaboloepigenetics, SLC transporters

Education

  • 1997 BS (D.V.M.), Seoul National University College of Veterinary Medicine
  • 1999 MS, Seoul National University College of Veterinary Medicine
  • 2003 Ph.D., The University of Tokyo (Veterinary Medicine: Biomedical Sciences)

Career

  • 2004–2007 Postdoctoral Fellow, Emory University School of Medicine, USA
  • 2008–2010 Associate Research Scientist, Yale University School of Medicine, USA
  • 2010– Present Professor, Seoul National University College of Medicine (Microbiology and Immunolgy/Biomedical Sciences)

Publication

  1. Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway, Exp Mol Med. 2024. Accepted.
  2. Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis. Sci Signal. 2022 Jan 11;15(716):eabi7400.
  3. Anti-thymocyte globulin-mediated immunosenescent alterations of T cells in kidney transplant patients. Clin Transl Immunology. 2022 Nov 24;11(11):e1431.
  4. Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells. Elife. 2021 Jan 28;10:e61841.
  5. Senescent T Cells Predict the Development of Hyperglycemia in Humans. Diabetes. 2019 Jan;68(1):156-162.
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