Department of Biomedical Sciences, SNU
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Chang, sunghoe

Ph.D. / Professor
Laboratory of Neural Functions and Bioimaging
TEL +82-2-740-8918
FAX 02-3673-2167
E-MAIL sunghoe@snu.ac.kr
WEBSITE https://nfi0829snu.wixsite.com/nfisnu

Research

Research Field
In the department of physiology/neuroscience at Seoul National University College of Medicine, our laboratory, Laboratory of neural functions and bio-imaging (NFi), researches the mechanism of synaptic activity and neurotransmission of brain neurons by utilizing various research techniques.
Especially, we focus on studying the mechanism of neurotransmitter release at presynaptic neurons, structural and functional changes at postsynaptic neurons, and investigating specific protein functions which are related with neuropsychiatric, neurodevelopmental and neurodegenerative diseases such as autism spectrum disorder (ASD), bipolar disorder, and Alzheimer’s disease (AD). We are also developing novel methods of brain tissue clearing and antibody staining for effective and efficient brain imaging. To perform our research projects, we use live-cell imaging, super-resolution imaging (STORM, SIM), as well as biochemical, electrophysiological, molecular/cellular, and biophysical experimental techniques.
Pure Link
https://snucm.elsevierpure.com/en/persons/sunghoe-chang
Keyword
Synaptic physiology, Pre- and post-synaptic morphogenesis, Neurodegenerative diseases, Live-cell imaging/Super-resolution imaging, Tissue clearing/immunostaining
Intensive Major
# Physiology-Neurology
# Molecular cell

Education

  • 1991 M.S. in Biological Sciences (Microimmunology), Konkuk University
  • 2000 Ph.D. in Neurophysiology/Biophysics, University of Illinois Chicago

Career

  • 2000 - 2002 Postdoctoral Fellow in Cell biology & Neuroscience, Yale University
  • 2002 - 2009 Assistant Professor & Associate Professor in Life Sciences, Gwangju Institute of Science and Technology (GIST)
  • 2009 - Associcate Professor & Professor in Department of Physiology, Seoul National University School of Medicine

Publication

  1. SCAMP5 plays a critical role in axonal trafficking and synaptic localization of NHE6 to adjust quantal size at glutamatergic synapses. Proc. Natl. Acad. Sci USA. 2021; 118 (2)
  2. Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells. Nat. Commun. 2021; 12 (263)
  3. Impairment of Release Site Clearance within the Active Zone by Reduced SCAMP5 Expression Causes Short-Term Depression of Synaptic Release. Cell Rep. 2018; 22 (12)
  4. Activation of CaMKIV by soluble amyloid-β1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis. Sci Signal. 2017; 10 (487)
  5. nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. Proc. Natl. Acad. Sci USA. 2016; 113 (24)
List
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