Cho, chung-hyun
Ph.D. / Professor
Research
Research Field
In Vascular Microenvironment Lab, we study the cellular and molecular mechanisms of angiogenesis and vascular remodeling and related vascular diseases. Angiogenesis is an active process in the developmental stage, but angiogenesis in adults leads to exacerbating symptoms of various diseases, such as tumors and inflammation. Thus, it is an important therapeutic target for the diseases. More specifically, this laboratory is conducting research on the effects of angiogenic factors on vascular remodeling and their molecular mechanisms, as well as the mechanisms of interaction between vascular endothelial cells and various peripheral cells surrounding blood vessels. Through this, we try to conduct research on functional and molecular changes of vascular endothelial cells in pathological conditions such as cancer, diabetes, and inflammation.Keyword
Angiogenesis, Endothelial cell, Angiopoietin, Tumor angiogenesisIntensive Major
Education
- 1990~1997 B.S in Biology, Department of Biology, Chung-ang University
- 1997~1999 M.S in Molecular and Cellular Physiology, Department of Life Science, Pohang University of Science and Technology
- 1999~2004 Ph. D. in Molecular and Cellular Physiology, Division of Molecular and Life Science, Pohang University of Science and Technology
Career
- 2004~2006 PostDoc, KAIST
- 2006~2010 Assistant Professor, Department of Physiology, Chungnam National University College of Medicine
- 2010~present Professor, Department of Biomedical Science and Pharmacology, Seoul National Univeristy College of Medicine
Publication
- STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. J Cell Physiol. 2021 Oct;236(10):7058-7070.
- Interaction between microglia and retinal pigment epithelial cells determines the integrity of outer blood-retinal barrier in diabetic retinopathy. Glia. 2019 Feb;67(2):321-331.
- β-adrenergic receptor agonists attenuate pericyte loss in diabetic retinas through Akt activation. FASEB J. 2018 May;32(5):2324-2338.
- STAT3 activation in endothelial cells is important for tumor metastasis via increased cell adhesion molecule expression. Oncogene.2017 Sep28;36(39):5445-5459
- Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy. J Cell Physiol. 2017 May;232(5):1123-1134.
