Research Field

Our goal is to better understand the immune microenvironment in cancers utilizing advanced methodologies including in vivo imaging and single-cell genomics.
In particular, we aim to unveil the immense potential of myeloid populations in cancers, which is an emerging field. Real-time intravital multi-photon microscopy provides insight into dynamic cell migration and intercellular communication. We reveal the heterogeneity of myeloid cells through single-cell RNA sequencing in both pre-clinical and clinical specimens. This approach will provide novel avenues for immunotherapy of cancers by means of identifying promising targets in tumor immunity.

[Cancer Immunology]
In recent years, oncology research has seen immense progress due to the development of cancer immunology. Our lab has contributed to this revolution by discovering the vital role of myeloid cells in the tumor microenvironment, a previously unexplored area. We are currently leading the task of unveiling the immense potential of myeloid cells in cancers.

[In Vivo Imaging]
Furthermore, our lab utilizes intravital multi-photon microscopy to examine "real-life phenomena" that cannot be seen through conventional methods. With this state-of-the-art tool, we are able to conduct novel research by observing biological processes in living organisms, thus setting us apart from other labs.

[Drug Development]
The aforementioned use of cutting-edge imaging platforms allows us to delve into cancer immunology.
Our lab is interested in not only nurturing the basic sciences, but also advancing clinical research through drug development. Collaboration with the plethora of competent clinical doctors on campus will lead us to this end, especially in the field of translational medicine.

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Keyword

Cancer immunology, in vivo imaging, single-cell genomics, tumor microenvironment, drug development