Department of Biomedical Sciences, SNU
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Faculty

Bae, Sangsu

/ Associate Professor
Molecular Genome Engineering Laboratory
TEL +82-2-740-8238
FAX 02-3668-7897
E-MAIL sbae7@snu.ac.kr
WEBSITE https://sites.google.com/view/baelab/

Research

Research Field
"My work has been steadily focused on the development and application of CRISPR-related tools in a wide range of research areas. The Bae group aims to
1) develop novel genome editing tools,
2) apply CRISPR-based methods for the treatment of genetic diseases in vivo and ex vivo,
3) envision the center as a hub for genome editing technologies in different fields, including basic and applied research in plants and animals and in medical science."
Pure Link
https://snucm.elsevierpure.com/en/persons/sangsu-bae
Keyword
Genome editing, CRISPR, Gene therapy
Intensive Major
# Molecular cell
# Omics Medicine

Publication

  1. "Therapeutic base editing and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa" Molecular Therapy 30(8), 2664-2679 (2022). (Featured on the front cover)
  2. "Comprehensive analysis of prime editing outcomes in human embryonic stem cells"" Nucleic Acids Research 50(2), 1187-1197 (2022).
  3. "In vivo gene editing via homology-independent targeted integration for adrenoleukodystrophy treatment" Molecular Therapy 30(1), 119-129 (2022).
  4. "Quantitative assessment of engineered Cas9 variants for target specificity enhancement by single-molecule reaction pathway analysis" Nucleic Acids Research 49, 11312-11322 (2021).
  5. "High-purity production and precise editing of DNA base editing ribonucleoproteins" Science Advances 7(35), eabg2661 (2021).
  6. "Adenine base editors engineering reduces editing of bystander cytosines" Nature Biotechnology 39(11), 1426-1433 (2021).
  7. "Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease" Cell Stem Cell 28(9), 1614-1624 (2021). (Featured on the front cover)
  8. "PE-Designer and PE-Analyzer: Web-based design and analysis tools for CRISPR prime editing" Nucleic Acids Research 49(W1), W499–W504 (2021).
  9. "Adenine base editors catalyze cytosine conversions in human cells" Nature Biotechnology 37(10), 1145–1148 (2019).
  10. "Direct observation of DNA target searching and cleavage by CRISPR-Cas12a" Nature Communications 9, 2777 (2018).
List
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