Department of Biomedical Sciences, SNU
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Faculty

Bae, Sangsu

/ Professor
Molecular Genome Engineering Laboratory
TEL +82-2-740-8238
FAX 02-3668-7897
E-MAIL sbae7@snu.ac.kr
WEBSITE https://sites.google.com/view/baelab/

Research

Research Field
"My work has been steadily focused on the development and application of CRISPR-related tools in a wide range of research areas. The Bae group aims to
1) develop novel genome editing tools,
2) apply CRISPR-based methods for the treatment of genetic diseases in vivo and ex vivo,
3) envision the center as a hub for genome editing technologies in different fields, including basic and applied research in plants and animals and in medical science."
Pure Link
https://snu.elsevierpure.com/en/persons/sangsu-bae
Keyword
Genome editing, CRISPR, Gene therapy
Intensive Major
# Molecular cell
# Omics Medicine

Publication

  1. "Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing" Nature Biotechnology DOI: 10.1038/s41587-026-03301-2 (2026).
  2. "Engineered ADARs enable precision A-to-G base editing of DNA" Nature Biotechnology DOI: 10.1038/s41587-026-03223-z (2026).
  3. "Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity" Advanced Science 13(16):e21015 (2026).
  4. "AI-generated MLH1 small binder improves prime editing efficiency" Cell 188(21), 5831-5846 (2025).
  5. "Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases" Nature Biomedical Engineering 9(1), 79–92 (2025).
  6. "Comprehensive analysis of prime editing outcomes in human embryonic stem cells"" Nucleic Acids Research 50(2), 1187-1197 (2022).
  7. "Adenine base editor engineering reduces editing of bystander cytosines" Nature Biotechnology 39(11), 1426-1433 (2021).
  8. "Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease" Cell Stem Cell 28(9), 1614-1624 (2021). (Featured on the front cover)
  9. "High-purity production and precise editing of DNA base editing ribonucleoproteins" Science Advances 7(35), eabg2661 (2021).
  10. "Adenine base editors catalyze cytosine conversions in human cells" Nature Biotechnology 37(10), 1145–1148 (2019).
List
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