Yun-Sang, Lee - Faculty - Faculty - Department of Biomedical Sciences, Seoul National University Graduate School

Research

Research Field

Radiopharmaceutical chemistry (production of radioactive isotopes, labeling, analysis, efficacy evaluation)
Nanomedicine (biocompatible nanomaterials, radiolabeled nanopharmaceuticals)

In order to develop radiopharmaceuticals for diagnosis/therapy that can be used in nuclear medicine, we are developing radiopharmaceuticals/nanopharmaceuticals that can target specific disease areas. Currently, the research focus is on developing new medicines that can control the inflammatory response in the human body, and radiopharmaceuticals that can diagnose them are also being developed. In addition, we are developing combination drugs that can increase the effectiveness of immuno-anticancer drugs by targeting and diagnosing the tumor microenvironment and controlling them, and we are also conducting research on new radioactive nanopharmaceuticals capable of diagnostic combination therapy (theranostics).

Pure Link

https://snucm.elsevierpure.com/en/persons/y-lee-21

Keyword

Radiopharmaceutical Sciences, Nanomedcine

Intensive Major

# Molecular cell

# Infectious disease

Publication

Hyewon Chung, Ji Yong Park, Kyuwan Kim, Ran Ji Yoo, Minseok Suh, Gyo Jeong Gu, Jin Sil Kim, Tae Hyeon Choi, Jung Woo Byun, Young Wook Ju, Wonshik Han, Han Suk Ryu, Gehoon Chung, Do Won Hwang, Yujin Kim, Hye-Ryun Kang, Yi Rang Na, Hongyoon Choi, Hyung-Jun Im, Yun-Sang Lee*, and Seung Hyeok Seok*. Circulation Time-Optimized Albumin Nanoplatform for Quantitative Visualization of Lung Metastasis via Targeting of Macrophages. ACS Nano, 2022;16(8):12262-75.
Park JY, Song MG, Kim WH, Kim KW, Lodhi NA, Choi JY, Kim YJ, Kim JY, Chung H, Oh C, Lee YS, Kang KW, Im HJ, Seok SH, Lee DS, Kim EE, Jeong JM. Versatile and Finely Tuned Albumin Nanoplatform based on Click Chemistry. Theranostics. 2019 May 18;9(12):3398-3409.
Lodhi NA, Park JY, Kim K, Kim YJ, Shin JH, Lee YS, Im HJ, Jeong JM, Khalid M, Cheon GJ, Lee DS, Kang KW. Development of 99mTc-Labeled Human Serum Albumin with Prolonged Circulation by Chelate-then-Click Approach: A Potential Blood Pool Imaging Agent. Mol Pharm. 2019 Apr 1;16(4):1586-1595.
Sinyoung Jeong, Ji Yong Park, Myeong Geun Cha, Hyejin Chang, Yong-il Kim, Hyung-Mo Kim, Bong-Hyun Jun, Dong Soo Lee, Yoon-Sik Lee, Jae Min Jeong, Yun-Sang Lee, and Dae Hong Jeong. Highly Robust and Optimized Conjugation of Antibodies to Nanoparticles using Quantitatively Validated Protocols. Nanoscale, 2017;9:2548-555.
In Joon Lee, Ji Yong Park, Yong-il Kim, Yun-Sang Lee, Jae Min Jeong, Jaeil Kim, Euishin Edmund Kim, Keon Wook Kang, Dong Soo Lee, Seonji Jeong, Eun Jeong Kim, Young Il Kim, Jin Wook Chung. Image-based Analysis of Tumor Localization after Intra-arterial Delivery of Technetium-99m labeled SPIO using SPECT/CT and MRI. Mol Imaging, 2017;16:1-9."

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