Kim, Hyun Je - Faculty - Faculty - Department of Biomedical Sciences, Seoul National University Graduate School

Research

Research Field

Our research lab has established various types of 10x platforms (scRNAseq, snRNAseq, scATAC, multiome) for producing and analyzing data in-house. Targeted single cell proteomics (CyTOF) is produced by Mount Sinai HIMC. We have set up the GeoMX spatial transcriptomics platform to produce and analyze a vast amount of data. We actively utilize various domestic and international networks, including dermatology, immunology, and precision omics, to perform various national and private research and development projects. We are particularly interested in immune tolerance phenomena in chronic inflammatory diseases, acute viral infections (COVID19), and tumor immune responses, focusing on regulatory T cells. We also have expertise in transplant immunology, allogeneic transplantation, and CD40-CD40L signaling. Our goal is to develop medical scientists for medical school graduates and independent researchers with expertise in communication with physicians for non-medical school graduates.

Pure Link

https://snucm.elsevierpure.com/en/persons/hyun-je-kim

Keyword

scRNA seq, Spatial transcriptomics, Immune tolerance, regulatory T cell

Intensive Major

# Omics Medicine

# Immune

Publication

Lim Y, Kang SJ, Cho BK, Kim HJ, Mun JH, Roh MR, Gulati N, Yang HJ, Moon JH, Won CH, Park CG. Intra-tumoral heterogeneity and immune escape of melanoma arising from congenital melanocytic nevus revealed by spatial gene expression profiling. J Eur Acad Dermatol Venereol. 2022 Dec;36(12):e1044-e1047
Joo EH, Bae JH, Park JH, Bang YJ, Han J, Gulati N, Kim JI, Park CG, Park WY and Kim HJ. Deconvolution of Adult T-Cell Leukemia/Lymphoma With Single-CellRNA-Seq Using Frozen Archived Skin Tissue Reveals New Subset of Cancer Associated Fibroblast. Front. Immunol. 2022; 13:856363
Kim HJ**, Shim JH, Park JH, Shin HT, Shim JS, Jang KT, Park WY, Lee KH, Kwon EJ, Jang HS, Yang H, Lee JH, Yang JM, Lee D. Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Commun Biol. 2021 Jun 7;4(1):692
Czarnowicki T, Kim HJ, Villani AP, Glickman J, Duca ED, Han J, Pavel AB, Lee BH, Rahman AH, Merad M, Krueger JG, Guttman-Yassky E. High-dimensional analysis defines multicytokine T-cell subsets and supports a role for IL-21 in atopic dermatitis. Allergy. 2021 Apr 5
He H, Suryawanshi H, Morozov P, Gay-Mimbrera J, Del Duca E, Kim HJ, Kameyama N, Estrada Y, Der E, Krueger JG, Ruano J, Tuschl T, Guttman-Yassky E. Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis. J Allergy Clin Immunol. 2020 Jun;145(6):1615-1628

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