Research
Research Field
[The Cell Function Sensing and Therapy Laboratory] conducts research on the spatiotemporal molecular mechanisms of dynamic protein interactions and complex cellular functions related to various diseases through real-time cell imaging and optogenetics technology. To achieve this, we are developing fluorescent protein-based fluorescent molecular sensors and novel optogenetic techniques. Our goals are to understand the molecular-level pathological mechanisms of various diseases, and ultimately to develop gene/cell therapies that can finely regulate cellular functions for the treatement of diseases. To this end, we are conducting research to design key therapeutic proteins that can effectively control cell function.Keyword
Cell therapy, Therapeutic protein design, Protein dynamics, Cell function imaging, Fluorescent sensor, OptogeneticsPublication
- Seong J, Lin MZ (2021) Optobiochemistry: Genetically encoded optical control of protein activity by light. Annual Review of Biochemistry, 90:475-501
- Lee HN, Hyeon SJ, Kim HJ, Sim KM, Kim Y, Ju J, Lee J, Wang Y, Ryu H, Seong J (2022) Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington’s disease. Acta Neuropathologica,144(3):521-536
- Kim H, Nam MH, Jeong S, Lee H, Oh SJ, Kim J, Choi N, Seong J (2022) Differential receptor crosstalk in the DRD1-DRD2 heterodimer upon phasic and tonic dopamine signals. Progress in Neurobiology, 213:102266
- Ju J, Lee HN, Ning L, Ryu H, Zhou XX, Chun H, Lee YW, Lee-Richerson AI, Jeong C, Lin MZ, Seong J (2022) Optical regulation of endogenous RhoA reveals switching of cellular responses by signal amplitude. Cell Reports, 40(2):111080
- Kim HJ, Kim H, Choi J, Inn K-S, Seong J (2020) Visualization of autophagy progression by Red-Green-Blue autophagy sensor. ACS Sensors, 5(12):3850-3861