Department of Biomedical Sciences, SNU

Faculty

Faculty

Research

Research Field
Neurons are interconnected with one another to form neural circuits, functional entities of neuronal population, in the brain. Neural circuits respond to environmental stimuli and guide appropriate behaviors in animals. However, permanent alterations in neural circuit by biological or environmental factors produce abnormal behaviors and lead to psychiatric diseases. Dr. Myoung-Hwan Kim is currently investigating the interplay between gene, environment, and neural circuit using gene knockout mice to better understand the mechanism between permanent modification of neural circuits and psychiatric disease. Combining electrophysiology, cellular & molecular biology, and behavioral neurogenetics, Dr. Myoung-Hwan Kim’s group investigates gene-to-behavior pathways in psychiatric disease.
Main topics of research:
1) Neural mechanisms underlying stress susceptibility and behavioral despair
2) Intellectual disability in inheritable metabolic disease.
Keyword
Neuroscience, Synapse, Behavior, Electrophysiology, Neuropsychiatric disease

Education

  • 2001 B.A., Kyungpook National University, Genetic Engineering
  • 2005 Ph.D., Seoul National University College of Medicine, Physiology

Career

  • 2005-2006 PostDoc, Seoul National University College of Medicine, Physiology
  • 2006-2009 PostDoc, KAIST, Biological sciences
  • 2010 Assistant research professor, KAIST, Biological Sciences
  • 2018~2019 Visiting Assistant Professor, Yale University, School of Medicine
  • 2010~present Assistant professor, Associate professor, Seoul National University College of Medicine

Publication

  1. Yoon SH*, Song WS*, Oh SP, Kim YS, Kim MH. The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain. Mol Brain. 2021 Sep 15;14(1):142. (*equal contribution)
  2. Yoon SH, Bae YS, Oh SP, Song WS, Chang H, Kim MH. Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency. Sci Rep. 2021 Jan 13; 11(1):932.
  3. Kim KR, Lee SY, Yoon SH, Kim Y, Jeong HJ, Lee S, Suh YH, Kang JS, Cho H, Lee SH, Kim MH*, Ho WK*. Kv4.1, a Key Ion Channel for Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation. J Neurosci. 2020 Mar 11; 40(11):2200-2214. (*co-corresponding)
  4. YS Cho*, WS Song*, SH Yoon, KY Park, and MH Kim. Syringaresinol suppresses excitatory synaptic transmission and picrotoxin-induced epileptic activity in the hippocampus through presynaptic mechanisms. Neuropharmacology. 2018 Mar 15; 131, 68-82. (*equal contribution)
  5. YS Bae, SH Yoon, JY Han, J Woo, YS Cho, SK Kwon, YC Bae, D Kim, E Kim, and MH Kim. Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration. Genes Brain Behav. 2018 Feb; 17, 126-138.