Department of Biomedical Sciences, SNU

Faculty

Faculty

Research

Research Field
Our team investigates how structural and epigenetic changes in the genome regulate gene expression during human development and disease progression. We aim to understand the molecular mechanisms underlying the complex interactions between the three-dimensional genome architecture and epigenetic regulation.
Our lab develops cutting-edge experimental and computational approaches, leveraging multi-omics technologies and advanced bioinformatics tools. In particular, we utilize single-cell and spatial omics techniques to study how individual cells within tissues establish genome organization and epigenetic modifications that precisely control gene expression programs. By integrating these technologies, we seek to uncover novel molecular insights into various diseases, ultimately identifying potential diagnostic biomarkers and therapeutic targets.
Our interdisciplinary research bridges genomics, epigenomics, and computational biology, contributing broadly from basic biological understanding to clinical application.
Pure Link
Keyword
Epigenomics, Genomics, Single Cell Omics, Bioinformatics

Publication

  1. Temporally distinct 3D multi-omic dynamics in the developing human brain. Nature (2024) 624:125-134
  2. Foxp3 orchestrates reorganization of chromatin architecture to establish regulatory T cell identity. Nat Commun (2023) 14:7277
  3. Structural variants drive context-dependent oncogene activation in cancer. Nature (2022) 612:564-572
  4. Simultaneous profiling of 3D genome structure and DNA methylation in single human cells. Nat Methods (2019) 16:999-1006
  5. An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator. Nat Commun (2014) 5:5619