Department of Biomedical Sciences, SNU
KOR

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Kim, bum-joon

Ph.D. / Professor
Laboratory of Molecular Chronic Infectious Disease
TEL +82-2-740-8316
FAX 02-743-0881
E-MAIL kbumjoon@snu.ac.kr
WEBSITE https://biomed.snu.ac.kr/kbumjoon

Research

Research Field
Our laboratory focuses on understanding of underlying pathogenesis and development of preventive or therapeutic vaccines of pathogens leading to chronic infectious diseases, such as hepatitis B virus (HBV), hepatitis C virus (HCV), human immune deficiency virus (HIV) and mycobacteria including nontuberculous mycobacteria (NTM) and M. tuberculosis. We also try to develop new drug taking advantage of material derived from pathogen we are researching. Research themes of our laboratory are as follows.

Current Projects

1) Development of preventive and therapeutic vaccines for the mycobacterial diseases, tuberculosis and M. abscessus infections using a novel species, M. paragordonae
2) Development of therapeutic cancer vaccine using DNA vaccine
3) Development of therapeutic cancer vaccine using mycobacterial strains
4) Development of peptide derived vaccine adjuvants
5) Elucidation of virulent mechanisms of HBV genotype C infections focusing on the HBV variants
6) Elucidation of virulent mechanisms of M. abscessus infections focusing on Type I interferon signalings
Pure Link
https://snucm.elsevierpure.com/en/persons/bum-joon-kim
Keyword
Tuberculosis Vaccine, Cancer immunotherapy, Type 1 Interferon, Hepatitis B virus, hepatocellular carcinoma
Intensive Major
# Infectious disease
# Immune

Education

  • 1993, Bachelor of Agriculture, Seoul national university , College of Agriculture and Life Science
  • 1998, Doctor of Medicine, Seoul national university, College of Medicine (Microbiology)

Career

  • 2003, Assistant Professor, Seoul national university, college of medicine, microbiology department
  • 2009~2010 Visiting Professor, Yale university, college of medicine, Section of Rheumatology
  • 2010~ Professor, Seoul national university, college of medicine, microbiology department
  • 2021~ Director, Institute of Endemic Diseases

Publication

  1. Choi YM, Kim DH, Jang J, Kim BJ. A hepatitis B virus-derived peptide combined with HBsAg exerts an anti-HBV effect in an HBV transgenic mouse model as a therapeutic vaccine. Front Immunol. 2023 Jun 2;14:1155637.
  2. Lee MH, Kim BR, Seo H, Oh JH, Kim HL, Kim BJ. Live Mycobacterium paragordonae induces heterologous immunity of natural killer cells by eliciting type I interferons from dendritic cells via STING-dependent sensing of cyclic-di-GMP. Microbes Infect. 2023 Apr 27:105144.
  3. Kim DH, Choi YM, Jang J, Kim BJ. Global prevalence and molecular characteristics of three clades within hepatitis B virus subgenotype C2: Predominance of the C2(3) clade in South Korea. Front Microbiol. 2023 Mar 9;14:1137084.
  4. Choi YM, Kim DH, Jang J, Choe WH, Kim BJ. rt269L-Type hepatitis B virus (HBV) in genotype C infection leads to improved mitochondrial dynamics via the PERK-eIF2α-ATF4 axis in an HBx protein-dependent manner. Cell Mol Biol Lett. 2023 Mar 30;28(1):26.
  5. Cha GY, Seo H, Oh J, Kim BJ, Kim BJ. Potential Use of Mycobacterium paragordonae for Antimycobacterial Drug Screening Systems. J Microbiol. 2023 Jan;61(1):121-129.
List
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