Department of Biomedical Sciences, SNU


A. 항체공학
항체 약품, 단백질 공학, 기계학습 알고리즘을 이용한 면역 프로파일링
B. 항체 약품, 항체를 이용한 chimeric antigen receptor T (CAR-T) cell 치료제등의 개발을 진행하고 있으며, 기계 학습 알고리즘을 이용하여, 생물체 내의 항체 repertoire 분석도 진행하고 있다.
1개의 항체 약품 후보물질이 임상 2상 시험 중이며, 다수의 항체가 전임상 개발 중이다.
전공분야 핵심단어
Therapeutic antibody, Protein Engineering, Immune profiling with machine learning algorithm


  • 1988 서울대학교 의과대학 (의학사)
  • 1994 서울대학교 대학원 의학과 (의학박사)

주요 경력

  • 1999-2000 미국 The Scripps Research Institute (Research Associate)

주요 논문

  1. Jo DH, Kim JH, Yang W, Kim H, Chang S, Kim D, Chang M, Lee K, Chung J, Kim JH.
  2. Anti-complement component 5 antibody targeting MG4 domain inhibits choroidal
  3. neovascularization. Oncotarget. 2017; 8(28):45506-45516. PubMed [journal] PMID:
  4. , PMCID: PMC5542204
  5. Heo K, Min SW, Sung HJ, Kim HG, Kim HJ, Kim YH, Choi BK, Han S, Chung S, Lee ES,
  6. Chung J, Kim IH. An aptamer-antibody complex (oligobody) as a novel delivery
  7. platform for targeted cancer therapies. Journal of controlled release : official
  8. journal of the Controlled Release Society. 2016; 229:1-9. PubMed [journal] PMID:
  9. Kim S, Kim H, Jo DH, Kim JH, Kim SR, Kang D, Hwang D, Chung J. Bispecific
  10. anti-mPDGFRβ x cotinine scFv-Cκ-scFv fusion protein and
  11. cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert
  12. cytotoxicity against mPDGFRβ expressing cells. Methods (San Diego, Calif.). 2018;
  13. PubMed [journal] PMID: 30292795
  14. Jin J, Park G, Park JB, Kim S, Kim H, Chung J. An anti-EGFR × cotinine bispecific
  15. antibody complexed with cotinine-conjugated duocarmycin inhibits growth of
  16. EGFR-positive cancer cells with KRAS mutations. Experimental & molecular
  17. medicine. 2018; 50(5):67. PubMed [journal] PMID: 29795377, PMCID: PMC5967348
  18. Lee HK, Lee Y, Kim H, Lee HE, Chang H, Nam KT, Jeong DH, Chung J. Screening of
  19. Pro-Asp Sequences Exposed on Bacteriophage M13 as an Ideal Anchor for Gold
  20. Nanocubes. ACS synthetic biology. 2017; 6(9):1635-1641. PubMed [journal] PMID: